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The Kraus 2014 Nature paper established that NNMT is highly expressed in adipose tissue (especially in obesity) and that NNMT knockdown in adipose protects against diet-induced obesity in mice

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Low levels of zinc are associated with: Decreased levels of the thyroid hormones triiodothyronine (T3) and thyroxine (T4), as well as thyroid-stimulating hormone (TSH)

This study innovates the understanding of the significance of the self-elimination effect in metabolic regulation and tissue regeneration, and it also identified several small-molecule drugs such as KYP-2047, P3O, and GSH that can promote hair regeneration

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